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Updated: Mar 8, 2026

Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity
Published on: August 25, 2019
Resisting the Urge to Act: DREADDs Modifying Habits
Mark A G Eldridge1, Barry J Richmond1
1Section on Neural Coding and Computation, Laboratory of Neuropsychology, Bldg 49, Rm 1B80, NIMH/NIH/DHHS, Bethesda, MD, USA.
Abstract:
Recently, Meyer and Bucci used chemogenetic technology - artificial excitatory and inhibitory receptors - to modulate neuronal activity in two connected brain regions in opposite directions simultaneously. This innovative manipulation revealed that the two regions studied, orbitofrontal cortex and nucleus accumbens, are not sequentially dependent during contextual decision-making.
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