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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
Published on: August 20, 2019
[Evolutionary medicine: A new look on health and disease]
1UMR 5199 PACEA, université de Bordeaux, allée Geoffroy-Saint-Hilaire, 33615 Pessac cedex, France; Service d'hématologie, centre hospitalier de la Côte Basque, 64109 Bayonne cedex, France.
Abstract:
Evolutionary medicine represents an innovative approach deriving from evolutionary biology. It includes the initial Darwin's view, its actualization in the light of progresses in genetics and also dissident theories (i.e. non gene-based) particularly epigenetics. This approach enables us to reconsider the pathophysiology of numerous diseases, as for instance, infection, and our so-called diseases of civilization especially obesity, type 2 diabetes, allergy or cancer. Evolutionary medicine may also improve our knowledge regarding inter-individual variation in susceptibility to disease or drugs. Furthermore, it points out the impact of our behaviors and environment on the genesis of a series of diseases.
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