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Cerebral Hemispheres

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...

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Related Experiment Video

Updated: Mar 8, 2026

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

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Published on: August 11, 2016

Structural Connectivity Analysis in Children with Segmental Callosal Agenesis.

M Severino¹, D Tortora², B Toselli³

¹From the Neuroradiology Unit (M.S., D.T., G.M., A.R.) mariasavinaseverino@gaslini.org.

AJNR. American Journal of Neuroradiology

|January 21, 2017

Summary

This summary is machine-generated.

Segmental callosal agenesis, the absence of a brain segment, disrupts global connectivity and network organization. This study identified three subtypes and found reduced global connectivity and altered modularity in affected individuals.

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Area of Science:

Neuroimaging
Neuroscience
Developmental Neuroscience

Background:

Segmental callosal agenesis is a condition characterized by the absence of the intermediate portion of the corpus callosum.
The corpus callosum is crucial for interhemispheric communication in the brain.

Purpose of the Study:

To evaluate the structural connectivity in patients with segmental callosal agenesis.
To analyze the impact of this agenesis on brain network organization using advanced neuroimaging techniques.

Main Methods:

Utilized constrained spherical deconvolution tractography and connectome analysis on diffusion MRI data.
Reviewed clinical-radiologic features of 8 patients and compared structural connectivity metrics with 10 age-/sex-matched controls.

Main Results:

Identified three subtypes of segmental callosal agenesis based on hippocampal commissure position.
Found reduced global connectivity and disrupted modularity in patients compared to controls.
Observed increased variability in network topology and identified ectopic callosal bundles in some patients.

Conclusions:

Segmental callosal agenesis can be classified into three distinct malformative subtypes.
Even partial absence of the corpus callosum significantly impacts global brain connectivity and network modularity.
Ectopic callosal bundles may contribute to the observed interindividual variability in brain connectomes of affected individuals.