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The Promise of Proteomics in the Study of Oncogenic Viruses

Alison A McBride1

  • 1From the ‡Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, 33 North Drive, MSC3209, National Institutes of Health, Bethesda, Maryland 20892 amcbride@nih.gov.

Molecular & Cellular Proteomics : MCP
|January 21, 2017
PubMed

Insights

Viral proteomics offers insights into human cancer viruses like HPV and EBV. This approach helps identify viral oncoproteins, cellular targets, and potential diagnostic and therapeutic strategies for virus-induced cancers.

Area of Science:

  • Oncology and Virology: Focus on viral oncogenesis and host-pathogen interactions.

Background:

  • Approximately 15% of human cancers are linked to oncogenic viruses.
  • Persistent infections by human DNA viruses such as Human Papillomavirus (HPV), Merkel cell polyomavirus (McPyV), Epstein-Barr virus (EBV), and Kaposi's sarcoma-associated herpesvirus (KSHV) are significant contributors to cancer development.
  • These viruses encode oncoproteins that disrupt cellular pathways, promoting viral replication and immune evasion.

Purpose of the Study:

  • To explore the potential and challenges of applying viral proteomics to study oncogenic human DNA viruses.
  • To understand how viral oncoproteins manipulate host cellular pathways.
  • To identify novel diagnostic and therapeutic targets for virus-associated cancers.

Main Methods:

  • Utilizing viral proteomics to analyze host-pathogen interactions.
  • Investigating cellular pathways affected by persistent viral infections.
  • Identifying cellular proteins critical for viral persistence and oncogenesis.

Main Results:

  • Viral proteomics can elucidate cellular pathways perturbed by oncogenic viral infections.
  • This technique helps pinpoint cellular proteins essential for viral persistence and cancer development.
  • Key diagnostic and therapeutic targets can be identified through viral proteomic studies.

Conclusions:

  • Viral proteomics is a promising tool for understanding oncogenic viruses and their role in cancer.
  • The study of HPV, McPyV, EBV, and KSHV through proteomics can reveal crucial insights into viral mechanisms.
  • Identifying viral and cellular targets via proteomics holds potential for improved cancer diagnostics and treatments.

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