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Clinical utility of gene panel-based testing for hereditary myelodysplastic syndrome/acute leukemia predisposition

L Guidugli1, A K Johnson1, G Alkorta-Aranburu1

  • 1Department of Human Genetics, The University of Chicago, Chicago, IL, USA.

Leukemia
|January 21, 2017
PubMed
Abstract

No abstract available in PubMed .

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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