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A Web Tool for Generating High Quality Machine-readable Biological Pathways
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MPDB: Molecular Pathways Brain Database.

Gopal Madhana Vigneshwari1, Sankaranarayana Ramamoorthy1, Aarathy Muralikrishnan1

  • 1Centre of Excellence in Bioinformatics, School of Biotechnology, Madurai Kamaraj University, Madurai - 625021.

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|January 21, 2017
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Summary

The Molecular Pathways Brain Database (MPDB) offers organized molecular data for brain pathways. Analysis reveals independent molecular evolution in olfactory pathways, highlighting functional adaptation.

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Area of Science:

  • Neuroscience
  • Bioinformatics
  • Molecular Biology

Background:

  • Neuroscience research requires comprehensive molecular data for brain pathways.
  • Existing resources may lack organized, pathway-specific molecular information.
  • Neuro-informatics is crucial for managing and analyzing complex biological data.

Purpose of the Study:

  • To introduce the Molecular Pathways Brain Database (MPDB) as a novel resource.
  • To provide an organized platform for brain pathway molecular information.
  • To facilitate research in neuro-informatics.

Main Methods:

  • Compilation of molecular information for 1850 molecules.
  • Focus on three key sensory pathways: olfactory transduction, phototransduction, and long-term potentiation.
  • Analysis of the olfactory transduction pathway to demonstrate database utility.

Main Results:

  • The MPDB contains data on 1850 molecules across three sensory pathways.
  • Analysis of the olfactory pathway elucidated olfactory specificity.
  • Evidence suggests independent molecular evolution driven by functional needs.

Conclusions:

  • The MPDB is a valuable, free resource for neuro-informatics researchers.
  • The database aids in understanding molecular evolution and functional specificity in brain pathways.
  • MPDB supports advanced research in neuroscience and molecular biology.