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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

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Synchronous quintuple primary gastrointestinal tract malignancies: Case report.

Soo-Hong Kim¹, Byung-Soo Park¹, Hyun Sung Kim¹

¹Soo-Hong Kim, Byung-Soo Park, Hyun Sung Kim, Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, Gyungsangnam-do 50612, South Korea.

World Journal of Gastroenterology

|January 21, 2017

Summary

A rare case of synchronous quintuple primary malignancy involving the stomach, jejunum, and colon was successfully treated. This patient with multiple cancers is disease-free six years post-surgery and adjuvant therapy.

Keywords:

Colon neoplasm Small bowel neoplasm Stomach neoplasm Synchronous quintuple primary cancer

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Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment

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Published on: December 27, 2024

Area of Science:

Gastroenterology
Oncology
Pathology

Background:

Multiple primary malignancies, defined as two or more distinct cancers in one individual, are uncommon.
Synchronous quintuple primary malignancy, occurring simultaneously, represents an extremely rare clinical scenario.

Observation:

A 52-year-old male presented with anal pain and bloody stools.
Diagnostic workup revealed malignancies in the stomach, jejunum, ascending colon, transverse colon, and rectum.

Findings:

The patient underwent surgical resection including subtotal gastrectomy, jejunal resection, and total protocolectomy with end ileostomy.
Pathologic examination confirmed moderate differentiated gastric adenocarcinoma (Stage IA), combined adenocarcinoma and neuroendocrine carcinoma of the jejunum (Stage IIA), and mucinous adenocarcinomas in the ascending colon (Stage IIA), transverse colon (Stage I), and rectum (Stage IIIB).
Tumor analysis indicated Microsatellite Instability-High (MSI-H) presence, with intact MLH-1 and MSH-2 expression.

Implications:

The patient received adjuvant FOLFOX 4 chemoradiotherapy for advanced rectal cancer.
Six years post-treatment, the patient remains under regular follow-up with no evidence of recurrence or metastasis, highlighting the potential for successful management of synchronous quintuple primary malignancy.