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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Correlations between the MEG-A3 gene and incidence of breast cancer
Xinming Hou1, Feng Guo1, Qinghui Sun1
1Department of Thyroid and Breast Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, P.R. China.
Abstract:
The aim of the present study was to examine the interrelations between MEG-A3 gene and incidence of breast cancer. The expression of MEG-A3 gene in the tissue samples of patients with breast cancer and normal controls at RNA and protein levels was determined. Subsequently, the relative expression of RNA for the same patient was measured at different time-points (1, 3, 6, 8, 12 and 24 months), and the protein expression levels were determined using western blotting. The results showed that, the mRNA level in MEG-A3 gene of samples of patients with breast cancer was significantly higher than that of normal women (p<0.05). The MEG-A3 gene expression increased apparently with the prolongation and aggravation of the disease. In conclusion, there is a close correlation between MEG-A3 gene and the incidence of breast cancer; thus, MEG-A3 gene contributes to the occurrence and deterioration of breast cancer to some extent. It provides a theoretical basis for later disease treatment.
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