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Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor

Nicholas D Measom1, Kenneth D Down2, David J Hirst2

  • 1GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.; Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow, G1 1XL, U.K.

ACS Medicinal Chemistry Letters
|January 21, 2017
PubMed

Keywords:
LpPLA2bicyclo[1.1.1]pentanebioisosterecardiovascular diseasedarapladibphysicochemical

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