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A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
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GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile

Elisia Villemure1, Matthew Volgraf1, Yu Jiang2

  • 1Department of Discovery Chemistry, Department of Neurosciences, Department of Biochemical and Cellular Pharmacology, Department of Drug Metabolism and Pharmacokinetics, and Department of Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

ACS Medicinal Chemistry Letters
|January 21, 2017
PubMed

Keywords:
AMPARCNSEPSPNMDARPAMallostericbrain concentrationpotentiatorselectivity

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