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ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
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Recent advances in understanding neutrophils.
Justin F Deniset1, Paul Kubes2
1Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada.
F1000Research
|January 21, 2017
Summary
Neutrophils, once seen only in acute inflammation, now show diverse roles in adaptive immunity and chronic diseases. This review explores new neutrophil functions and tracking technologies.
Area of Science:
- Immunology
- Cell Biology
Background:
- Neutrophils are primary cells of innate immunity during acute inflammation.
- Emerging research indicates neutrophils possess broader functions beyond acute inflammation, impacting adaptive immunity and chronic conditions.
Purpose of the Study:
- To review evolving concepts in neutrophil research.
- To highlight advancements in understanding neutrophil behavior and function in vivo.
- To discuss novel immunomodulatory roles and technical innovations in neutrophil tracking.
Main Methods:
- Literature review of recent studies on neutrophil biology.
- Analysis of data on neutrophil subsets, polarization, and immunomodulation.
- Identification of emerging technologies for in vivo neutrophil analysis.
Main Results:
- Neutrophils exhibit functional diversity, including roles in adaptive immunity and chronic pathologies.
- Neutrophil subsets and polarization are key to their diverse functions.
- Novel immunomodulatory activities of neutrophils are being uncovered.
- Technical advances are improving the tracking of neutrophil function and fate.
Conclusions:
- Neutrophil research has evolved significantly, revealing complex roles in immunity.
- Understanding neutrophil heterogeneity and plasticity is crucial.
- Future technical developments will enhance the study of neutrophils in vivo.
