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Animal models for the study of primary and secondary hypertension in humans

Hiu Yu Lin1, Yee Ting Lee1, Yin Wah Chan2

  • 1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, P.R. China.

Biomedical Reports
|January 21, 2017
PubMed

Insights

This review examines animal models for studying hypertension, a global health issue defined by high blood pressure. Understanding these models aids research into hypertension

Area of Science:

  • Cardiovascular Science
  • Nephrology
  • Genetics

Background:

  • Hypertension is a major global cause of illness and death.
  • It is defined as elevated systolic and diastolic blood pressures (SBP/DBP).
  • Causes include primary (multifactorial) and secondary (e.g., renal, endocrine) factors.

Purpose of the Study:

  • To review and discuss various animal models used in hypertension research.
  • To analyze the advantages, disadvantages, and limitations of these models.

Main Methods:

  • Literature review of existing animal models for hypertension.
  • Analysis of model utility for studying molecular and physiological mechanisms.

Main Results:

  • Various animal models exist for hypertension research.
  • Each model offers unique insights but also has limitations.

Conclusions:

  • Animal models are crucial for understanding hypertension.
  • Careful selection of models is necessary for effective research into hypertension's mechanisms.

Keywords:
animal modelsendotheliumhypertensionmouseratvascular function

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