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Related Concept Videos

Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Updated: Mar 8, 2026

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
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Cutaneous osteosarcoma arising from a burn scar.

Min A Lee1,2, Jaehyuck Yi3,4, Jong Min Chae5

  • 1Department of Radiology, College of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.

Skeletal Radiology
|January 21, 2017
PubMed
Summary

Malignant tumors in old burn scars are typically squamous cell carcinomas. This report details the first case of cutaneous osteosarcoma, a rare bone cancer, identified through imaging in a burn scar.

Keywords:
Burn scarCTCutaneous osteosarcomaExtraskeletal osteosarcomaMRISoft-tissue mass with mineralization

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Area of Science:

  • Oncology
  • Radiology
  • Dermatopathology

Background:

  • Tumors in chronic burn scars are predominantly squamous cell carcinomas.
  • Rarely, sarcomas can arise in burn scars.
  • Extraskeletal osteosarcoma in burn scars is exceptionally rare, with limited prior case reports focusing on clinicopathology.

Observation:

  • A case of cutaneous osteosarcoma presented as a mineralized soft-tissue mass.
  • The tumor originated in a scar from a previous skin burn on the patient's back.
  • Imaging characteristics of this rare tumor were visualized.

Findings:

  • This case represents the first description of the imaging features of cutaneous osteosarcoma arising in a burn scar.
  • The tumor manifested as a distinct mineralized mass on imaging.
  • Confirms the possibility of diverse rare malignancies developing in chronic scar tissue.

Implications:

  • Highlights the importance of considering rare malignancies in the differential diagnosis of chronic burn scar lesions.
  • Emphasizes the role of advanced imaging in characterizing unusual soft-tissue masses in scar sites.
  • Contributes to the understanding of oncogenesis in chronic inflammatory conditions and scar tissue.