Related Experiment Video
Updated: Mar 8, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Ropinirole in Bipolar Disorder: Rate of Manic Switching and Change in Disease Severity
Horacio A Capote1, Michelle Rainka2, Erica S Westphal3
1Director, Neuropsychiatry Division, Dent Neurologic Institute, Buffalo, New York, USA.
Purpose:
To determine the effects of ropinirole on manic switching and disease severity in bipolar disorder.
Design And Methods:
A cross-sectional survey was conducted in 23 bipolar depressed patients using ropinirole combination therapy (Young Mania Rating Scale [YMRS], Bipolar Inventory of Symptoms Scale [BISS]). Retrospective Clinical Global Impression of Change (CGI-C) and CGI-S (Severity) were captured via chart review.
Findings:
One patient (4.3%) experienced induction of mania (YMRS). All patients responded or partially responded to ropinirole (CGIs). YMRS and BISS mania scores were correlated.
Practice Implications:
Ropinirole has a low rate of manic switching and significantly reduces bipolar depression severity.
Related Concept Videos
Mania and Antimanic Drugs: Overview
Bipolar Disorder
Psychosis: Goals of Pharmacotherapy
Psychosis and Antipsychotic Drugs: Overview
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Drug Therapy
Antianxiety Medications

