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Relationship between mean platelet volume and ischemic stroke in patients with patent foramen ovale

Nermin Bayar1, Selçuk Küçükseymen, Zehra Erkal

  • 1Department of Cardiology, Antalya Training and Research Hospital, Antalya, Turkey. dr.nermin@mynet.com.

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|January 21, 2017
PubMed
Abstract

Insights

Mean platelet volume (MPV) is higher in patients with patent foramen ovale (PFO) who experience stroke or TIA. This finding may help identify PFO patients at high risk for cardioembolic stroke.

Area of Science:

  • Cardiology
  • Neurology
  • Hematology

Background:

  • Patent foramen ovale (PFO) is frequently observed in cryptogenic stroke patients.
  • Mean platelet volume (MPV), a marker of platelet reactivity, is elevated in individuals with PFO compared to the general population.

Purpose of the Study:

  • To determine if MPV differs between patients with PFO and stroke/TIA (symptomatic) and those with asymptomatic PFO.
  • To evaluate MPV as a potential indicator for symptomatic PFO.

Main Methods:

  • Retrospective analysis of 108 patients under 55 with PFO.
  • Comparison of hemogram parameters, specifically MPV, between symptomatic (stroke/TIA) and asymptomatic PFO groups.

Main Results:

  • MPV was significantly higher in the symptomatic PFO group (median 10.0 fl) versus the asymptomatic group (median 8.56 fl).
  • An MPV cut-off of 9.0 fl demonstrated 70% sensitivity and 86% specificity for identifying symptomatic PFO.

Conclusions:

  • Elevated MPV is associated with symptomatic PFO.
  • MPV may serve as a supplementary risk factor for identifying PFO patients at elevated risk of cardioembolic stroke.

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