Application of 3D and 2D quantitative shear wave elastography (SWE) to differentiate between benign and malignant...

As breast cancer tissues are stiffer than normal tissues, shear wave elastography (SWE) can locally quantify tissue stiffness and provide histological information. Moreover, tissue stiffness can be observed on three-dimensional (3D) colour-coded elasticity maps. Our objective was to evaluate the diagnostic performances of quantitative features in differentiating breast masses by two-dimensional (2D) and 3D SWE. Two hundred ten consecutive women with 210 breast masses were examined with B-mode ultrasound (US) and SWE. Quantitative features of 3D and 2D SWE were assessed, including elastic modulus standard deviation (E_SD^E) measured on SWE mode images and E_SD^U measured on B-mode images, as well as maximum elasticity (E_max). Adding quantitative features to B-mode US improved the diagnostic performance (p < 0.05) and reduced false-positive biopsies (p < 0.0001). The area under the receiver operating characteristic curve (AUC) of 3D SWE was similar to that of 2D SWE for E_SD^E (p = 0.026) and E_SD^U (p = 0.159) but inferior to that of 2D SWE for E_max (p = 0.002). Compared with E_SD^U, E_SD^E showed a higher AUC on 2D (p = 0.0038) and 3D SWE (p = 0.0057). Our study indicates that quantitative features of 3D and 2D SWE can significantly improve the diagnostic performance of B-mode US, especially 3D SWE E_SD^E, which shows considerable clinical value.