Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.6K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
5.6K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.8K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.8K
Development of Blood Vessels01:07

Development of Blood Vessels

1.6K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
1.6K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

7.3K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
7.3K
Tooth Anatomy01:21

Tooth Anatomy

2.5K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
2.5K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Different metabolite profiles across Penicillium roqueforti populations associated with ecological niche specialisation and domestication.

IMA fungus·2024
Same author

The integrative taxonomy of <i>Beauveria asiatica</i> and <i>B. bassiana</i> species complexes with whole-genome sequencing, morphometric and chemical analyses.

Persoonia·2023
Same author

Odontoblast cell death induces NLRP3 inflammasome-dependent sterile inflammation and regulates dental pulp cell migration, proliferation and differentiation.

International endodontic journal·2021
Same author

A connectivity mapping approach predicted acetylsalicylic acid (aspirin) to induce osteo/odontogenic differentiation of dental pulp cells.

International endodontic journal·2020
Same author

An international survey on the use of calcium silicate-based sealers in non-surgical endodontic treatment.

Clinical oral investigations·2019
Same author

C5L2 Regulates DMP1 Expression during Odontoblastic Differentiation.

Journal of dental research·2019
Same journal

Gold Nanoparticles Enhance the Antibacterial and Osteogenic Properties of Polyetheretherketone.

Journal of dental research·2026
Same journal

Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis.

Journal of dental research·2026
Same journal

Response to Letter to Editor: "Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal Machine Learning".

Journal of dental research·2026
Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026
Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: Mar 8, 2026

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
14:52

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

27.3K

Pulp Vascularization during Tooth Development, Regeneration, and Therapy.

C Rombouts1, T Giraud1,2, C Jeanneau1

  • 11 Aix Marseille Univ, CNRS, ISM, Inst Movement Sci, Marseille, France.

Journal of Dental Research
|January 21, 2017
PubMed
Summary
This summary is machine-generated.

Pulp vascularization, crucial for tooth health and regeneration, is driven by angiogenesis, particularly in therapeutic settings. Dental pulp stem cells actively promote this process through their secretome.

Keywords:
angiogenesispulp biologystem cell(s)tissue engineeringtooth regeneration/transplantationvascular biology

More Related Videos

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

12.0K
Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
03:45

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Published on: May 5, 2023

3.4K

Related Experiment Videos

Last Updated: Mar 8, 2026

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
14:52

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

27.3K
Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

12.0K
Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
03:45

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Published on: May 5, 2023

3.4K

Area of Science:

  • Oral Biology
  • Vascular Biology
  • Regenerative Medicine

Background:

  • The dental pulp is a highly vascularized tissue essential for nutrient supply, waste removal, and inflammatory responses.
  • Pulp vascularization is critical for tooth development, regeneration, and therapeutic interventions like tissue engineering and transplantation.

Purpose of the Study:

  • To review the mechanisms of pulp vascularization during tooth development, regeneration, and therapeutic procedures.
  • To highlight the role of hypoxia and proangiogenic factors, including vascular endothelial growth factor (VEGF).
  • To discuss the contribution of dental pulp stem cells (DPSCs) to pulp revascularization.

Main Methods:

  • Review of existing literature on pulp vascularization mechanisms.
  • Analysis of the roles of vasculogenesis, sprouting angiogenesis, hypoxia, and growth factors.
  • Examination of the angiogenic potential of dental pulp stem cells and their secretome.

Main Results:

  • Vasculogenesis establishes pulp vasculature during embryonic development; sprouting angiogenesis predominates during regeneration and therapy.
  • Hypoxia is a key driver, stimulating dental pulp cells to release proangiogenic factors like VEGF.
  • Dental pulp stem cells possess significant angiogenic potential, guiding endothelial cells and potentially differentiating into endothelial cells.

Conclusions:

  • Pulp vascularization involves complex mechanisms, with angiogenesis being central to regenerative and therapeutic processes.
  • Dental pulp stem cells and their secretome are vital contributors to pulp revascularization.
  • Further research is needed to fully elucidate signaling pathways, timing, and the impact of stress conditions on pulp vascularization.