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Facilitated Diffusion of Transcription Factor Proteins with Anomalous Bulk Diffusion

Lin Liu1,2, Andrey G Cherstvy2, Ralf Metzler2

  • 1CAS Key Laboratory of Soft Matter Chemistry, Dept. of Polymer Science and Engineering, University of Science and Technology of China , Hefei, Anhui Province 230026, China.

The Journal of Physical Chemistry. B
|January 21, 2017
PubMed
Summary

Proteins find DNA targets faster with optimal binding affinity and anomalous diffusion. Macromolecular crowding influences protein search dynamics, balancing 3D diffusion and 1D sliding for efficient binding.

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