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[Plasma morphine levels during its continuous epidural infusion].

T Murakawa, S Baba, K I Isozaki

    Masui. the Japanese Journal of Anesthesiology
    |September 1, 1989
    PubMed
    Summary

    Continuous epidural morphine provided effective postoperative pain relief in adult patients. Plasma morphine levels remained below analgesic concentrations, indicating a safe and efficient delivery method for pain management.

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    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Pain Management

    Context:

    • Postoperative pain management is crucial for patient recovery.
    • Continuous epidural infusion offers a method for sustained drug delivery.
    • Morphine is a common opioid analgesic used for severe pain.

    Purpose:

    • To evaluate plasma morphine levels during continuous epidural infusion for postoperative analgesia.
    • To assess the safety and efficacy of this pain management technique.
    • To correlate plasma morphine concentrations with analgesic effects.

    Summary:

    • Nine adult patients received continuous epidural morphine post-surgery.
    • Plasma morphine levels were measured using gas chromatography-mass spectrometry.
    • Concentrations were generally below the minimum analgesic threshold (10-40 ng/mL) and no severe adverse events like respiratory depression were observed.

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    Impact:

    • Continuous epidural morphine can provide adequate analgesia at low plasma concentrations.
    • This method appears safe, with plasma levels below toxic thresholds.
    • Findings suggest the analgesic effect of epidural morphine may not directly correlate with plasma concentration.