Related Experiment Videos
[A clinical experience of ofloxacin in patients with respiratory infection]
K Tanaka1, H Suzuki, S Shimizu
1Department of Respiratory Internal Medicine, Fujigaoka Hospital, Showa University.
Abstract:
To a total of 31 patients (18 in- and 13 out-patients) having respiratory infections, we administered ofloxacin (OFLX) orally at a daily dose of 300 to 600 mg and examined its clinical effect. The clinical effect in the 31 cases was as good as 83.9%. Among these cases, 6 cases showed Pseudomonas aeruginosa, thereby indicating the effective rate of OFLX at 50%. In the present examination, we experienced cases in which OFLX-resistant P. aeruginosa appeared in the cases of long-term administration of OFLX. Therefore, our clinic carried out the sensitivity test of P. aeruginosa against OFLX, gentamicin (GM) and imipenem (IPM) in 1987, using clinically-segregated strains of P. aeruginosa obtained by sputum tests. The sensitive strains, which were 100% sensitive to OFLX, GM, IPM respectively in 1985, showed, in segregated strains in 1987, sensitivity of OFLX 57.1%, GM 85.7% and IPM 100%, thus indicating the high resistance-acquiring frequency of P. aeruginosa against OFLX.
Insights
Ofloxacin showed an 83.9% clinical effect for respiratory infections. However, Pseudomonas aeruginosa developed resistance to ofloxacin over time, highlighting a significant challenge in antibiotic efficacy.
Area of Science:
- Infectious Diseases
- Pharmacology
- Microbiology
Context:
- Respiratory infections pose a significant public health challenge.
- Antibiotic resistance is a growing concern in treating bacterial infections.
- Ofloxacin is a commonly prescribed antibiotic for various infections.
Purpose:
- To evaluate the clinical efficacy of ofloxacin (OFLX) in patients with respiratory infections.
- To investigate the emergence of ofloxacin resistance in Pseudomonas aeruginosa strains.
- To compare the in vitro sensitivity of P. aeruginosa to ofloxacin, gentamicin (GM), and imipenem (IPM) over time.
Summary:
- A study administered ofloxacin to 31 patients with respiratory infections, achieving an 83.9% clinical effect.
- Pseudomonas aeruginosa isolates showed a decrease in sensitivity to ofloxacin from 100% in 1985 to 57.1% in 1987.
- In contrast, sensitivity to gentamicin and imipenem remained high, indicating a high frequency of resistance acquisition against ofloxacin.
Impact:
- The findings highlight the potential for rapid development of ofloxacin resistance in P. aeruginosa.
- This underscores the importance of monitoring antibiotic resistance patterns.
- Judicious use of antibiotics and development of new therapeutic strategies are crucial to combat rising resistance.