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[Clinical observations with cefteram pivoxil granules in field of pediatrics]
A Nakazato1, R Fujino, K Maeda
1Department of Pediatrics, Saitama Medical School.
Insights
A new oral antibiotic, cefteram pivoxil (CFTM-PI), demonstrated high efficacy (95.7%) in treating various pediatric bacterial infections. This antibiotic showed promising results with minimal adverse effects in clinical trials.
Area of Science:
- Pediatric infectious diseases
- Pharmacology of novel antibiotics
- Clinical microbiology
Context:
- Acute bacterial infections are common in pediatric populations.
- The need for effective and safe oral antibiotics in children is significant.
- Cefteram pivoxil (CFTM-PI) is an emerging oral cephem antibiotic.
Purpose:
- To evaluate the clinical efficacy and safety of cefteram pivoxil (CFTM-PI) in pediatric patients.
- To assess the effectiveness of CFTM-PI against a range of acute bacterial infections in children.
Summary:
- A clinical study involved 23 pediatric patients with acute bacterial infections, including tonsillitis, bronchitis, scarlet fever, bronchopneumonia, otitis media with sinusitis, and urinary tract infections.
- Patients received oral cefteram pivoxil (CFTM-PI).
- The treatment achieved an overall efficacy rate of 95.7% ('excellent' in 8, 'good' in 14), with diarrhea reported in only one patient.
Impact:
- Cefteram pivoxil (CFTM-PI) shows potential as a valuable therapeutic option for pediatric bacterial infections.
- The findings support the use of CFTM-PI in pediatric clinical practice.
- Further research may explore its role in broader pediatric infectious disease management.
Abstract:
A new oral cephem antibiotic, cefteram pivoxil (CFTM-PI, T-2588), was studied for clinical efficacy in the field of pediatrics. CFTM-PI was given orally to 23 patients with the following acute bacterial infections: 6 cases of acute tonsillitis, 8 of acute bronchitis, 2 of scarlet fever, 4 of bronchopneumonia, 1 of acute otitis media with sinusitis and 2 of urinary tract infections. Clinical results were "excellent" in 8, "good" in 14, "poor" in 1: the efficacy rate was 95.7%. As an adverse reaction, diarrhea was observed in 1 patient. From the above clinical results, it appears that CFTM-PI is a useful antibiotic for the treatment of pediatric patients with various bacterial infections.