Related Experiment Videos
[Clinical studies on cefteram pivoxil in the field of pediatrics]
T Shinozaki1, C Nonaka, K Togasaki
1Department of Pediatrics, Tokyo Kosei-Nenkin Hospital.
Insights
Cefteram pivoxil demonstrated good clinical effects in patients with respiratory and urinary tract infections. This antibiotic achieved significant bacterial eradication, with mild diarrhea as the main side effect observed.
Area of Science:
- Infectious Diseases
- Pharmacology
- Microbiology
Context:
- Respiratory infections and urinary tract infections are common ailments.
- Antibiotic resistance necessitates the evaluation of new therapeutic agents.
- Cefteram pivoxil is an oral cephalosporin antibiotic.
Purpose:
- To evaluate the clinical and bacteriological efficacy of Cefteram pivoxil.
- To assess the safety profile of Cefteram pivoxil in patients.
- To determine the effectiveness of Cefteram pivoxil against common bacterial pathogens.
Summary:
- Cefteram pivoxil was administered to 40 patients with respiratory or urinary tract infections at 10 mg/kg/day.
- Good clinical effects were observed in all patients.
- Bacteriological evaluation showed eradication of 60.0% of identified bacterial strains, including Escherichia coli, though Staphylococcus aureus eradication was limited. Mild diarrhea was noted in four cases.
Impact:
- Cefteram pivoxil shows promise as an effective treatment for certain bacterial infections.
- Further research may be needed to optimize its use against specific pathogens like Staphylococcus aureus.
- The study contributes to understanding the clinical utility of Cefteram pivoxil in common infections.
Abstract:
Cefteram pivoxil (CFTM-PI) was administered to 37 patients with acute febrile upper or lower respiratory infections and 3 patients with urinary tract infections at 10 mg/kg/day divided into 3 portions. Good clinical effects were observed in all the cases. As for the bacteriological effect, the evaluable 24 strains (60.0%) were eradicated among 43 strains identified in 37 cases with the treatment with CFTM-PI. Only 2 strains were eradicated among 9 strains of Staphylococcus aureus. Among 3 patients with urinary tract infections with Escherichia coli, 2 strains were eradicated from urine after the administration of CFTM-PI. Four cases showed mild diarrhea among 40 cases. It was not clear whether the diarrhea was due to the administration of CFTM-PI.