Related Experiment Videos
[A clinical study on cefteram pivoxil granule in the field of pediatrics]
Insights
Cefteram pivoxil (CFTM-PI) is an effective oral antibiotic for pediatric bacterial infections, showing a 92.9% efficacy rate with no observed side effects in a study of 17 children.
Area of Science:
- Pediatric infectious diseases
- Pharmacology of cephalosporins
Context:
- The study investigates the clinical utility of a novel oral cephalosporin antibiotic, cefteram pivoxil (CFTM-PI), in pediatric patients.
- Bacterial infections in children require effective and safe oral treatment options.
Purpose:
- To evaluate the clinical effectiveness and safety of cefteram pivoxil (CFTM-PI) granule in treating bacterial infections in pediatric patients.
- To assess the palatability and tolerability of CFTM-PI in children.
Summary:
- CFTM-PI was administered to 17 pediatric patients at daily doses ranging from 9.5 to 31.8 mg/kg for 2 to 10 days.
- Clinical efficacy was assessed in 14 patients, with an overall efficacy rate of 92.9% (8 excellent, 5 good, 1 fair).
- No adverse side effects were reported in any of the 17 patients; one patient showed a slight elevation in blood platelet count. The granule formulation was well-accepted by children regarding taste and odor.
Impact:
- Cefteram pivoxil (CFTM-PI) demonstrates significant clinical effectiveness and a favorable safety profile for treating pediatric bacterial infections.
- The positive results suggest CFTM-PI is a valuable addition to the pediatric antibiotic armamentarium, offering a well-tolerated oral option.
Abstract:
The clinical effectiveness of cefteram pivoxil (CFTM-PI) granule, a new oral cephalosporin, was studied in pediatric patients. The results are summarized as follows. 1. CFTM-PI was given orally to 17 children in daily doses of 9.5 to 31.8 mg/kg in 3 to 4 divided portions for 2 to 10 days. Clinical evaluations were made on 14 patients. Clinical effects of CFTM-PI were excellent in 4, good in 5 of 9 patients with tonsillitis or pharyngitis, excellent in all cases of 2 patients with pneumonia, 1 patient with scarlet fever and 1 patient with pyelonephritis, and fair in 1 patient with purulent cervical lymphadenitis. Overall clinical effects were excellent in 8, good in 5, and fair in 1 with an efficacy rate of 92.9%. 2. No side effects were observed in any of the 17 patients. Hematological tests showed a slight elevation of blood platelet counts in 1 patient. 3. The taste and odor of CFTM-PI granule were well accepted by the children. 4. CFTM-PI is a useful oral antibiotic for the treatment of bacterial infections in pediatrics.