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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
131

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Peptide-Based Stealth Nanoparticles for Targeted and pH-Triggered Delivery.

Alessandro Ranalli1, Melissa Santi1, Luigi Capriotti2

  • 1NEST, Scuola Normale Superiore and Istituto Nanoscienze-CNR , Piazza San Silvestro 12, Pisa 56127, Italy.

Bioconjugate Chemistry
|January 21, 2017
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Summary

This study introduces a novel lipopeptide that creates stable, non-PEGylated nanostructures for drug delivery. These biocompatible nanovesicles outperform PEGylated liposomes by reducing immune reactions and improving targeted delivery efficacy.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Stealth agents like poly(ethylene glycol) (PEG) prolong nanostructure circulation but can cause immune reactions and reduce targeting efficiency.
  • There is a need for biocompatible, non-PEGylated alternatives for enhanced targeted drug delivery using liposomal technology.

Purpose of the Study:

  • To develop and characterize a novel lipopeptide-based nanostructure for improved liposomal drug delivery.
  • To evaluate the stability, biocompatibility, and targeting efficiency of the novel nanovesicles compared to PEGylated liposomes.

Main Methods:

  • A lipopeptide was formulated with common lipids (20-60% w/w) to create stable vesicles.
  • The peptide coating's ability to limit serum protein adsorption was tested under physiological conditions.
  • Vesicles were derivatized with an anti-transferrin receptor aptamer for targeted delivery.
  • Cellular internalization and pH-triggered doxorubicin release were evaluated.

Main Results:

  • The resulting lipopeptide-lipid vesicles demonstrated excellent thermal and chemical stability.
  • The peptide coating significantly reduced serum protein adsorption, outperforming PEGylated liposomes.
  • Derivatized vesicles exhibited highly selective cellular uptake via the transferrin receptor pathway.
  • pH-triggered release of doxorubicin was successfully achieved.

Conclusions:

  • The novel lipopeptide nanostructures offer a promising biocompatible and non-PEGylated alternative for advanced drug delivery systems.
  • These nanovesicles provide enhanced stability, reduced immunogenicity, and improved targeted delivery capabilities.
  • The platform allows for straightforward bio-orthogonal conjugation, enabling versatile functionalization for specific therapeutic applications.