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Multiple primary pulmonary meningiomas: 20-year follow-up findings for a first reported case confirming a benign
Yukitoshi Satoh1, Yuichi Ishikawa2
1Department of Thoracic Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan.
Introduction:
Primary pulmonary meningiomas (PPMs) are very rare neoplasms, and we reported the first multiple case of PPMs in 1998. Usually, PPMs are slow-growing tumors with a good prognosis. Herein, we reported a rare multiple case of PPMs with an extremely long clinical course.
Presentation Of The Case:
An 84-year-old Japanese woman with a history of multiple PPMs histologically confirmed as having a right-sided slowly growing lung nodule for 20 years. In 2010, we also reported the additional clinical course in the initial case 10 years after surgery implying a benign biological nature. Subsequent to that report, new lesions appeared in the bilateral lung fields with quite a slow growth rate. She was asymptomatic, and no tumor was observed in the cranial cavity during the course of her disease.
Discussion And Conclusion:
This case illustrates rare multiple PPMs and highlights their biological behavior with very slow progression from a most likely benign tumor over a 20-year period.
Insights
This case study details a rare instance of multiple primary pulmonary meningiomas (PPMs) in a patient over 20 years. The findings highlight the slow-growing, benign nature of these rare lung tumors.
Area of Science:
- Pulmonary Medicine
- Neoplastic Diseases
- Surgical Pathology
Background:
- Primary pulmonary meningiomas (PPMs) are exceptionally rare neoplasms.
- The first reported multiple case of PPMs was in 1998.
- PPMs typically exhibit slow growth and a favorable prognosis.
Purpose of the Study:
- To report a rare case of multiple primary pulmonary meningiomas with an extended clinical course.
- To illustrate the long-term biological behavior of PPMs.
Main Methods:
- Case report of an 84-year-old Japanese woman with a 20-year history of multiple PPMs.
- Review of clinical course, including initial diagnosis, subsequent lesion development, and imaging findings.
- Histological confirmation of PPMs.
Main Results:
- The patient presented with multiple PPMs, with initial lesions observed for 20 years.
- New bilateral lung lesions developed over time, demonstrating a very slow growth rate.
- The patient remained asymptomatic, and no intracranial tumors were detected.
Conclusions:
- This case underscores the rarity of multiple PPMs.
- It highlights the typically benign biological behavior and extremely slow progression of PPMs over extended periods.
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