Jove
Visualize
Contact Us

Related Experiment Videos

Ventricular aneurysms: a geometrical-dynamical model.

H E Castagnino1, F A Toranzos

  • 1Department of Medicine, Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

The Japanese Journal of Experimental Medicine
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Great expectations from a different approach to the treatment of acute myocardial infarction : cytoprotection.

International journal of cardiology·1999
Same author

Reduced injury and scar in acute myocardial infarctions treated with human growth hormone.

Japanese heart journal·1999
Same author

[William Osler and angina pectoris: still prevailing concepts].

Archivos del Instituto de Cardiologia de Mexico·1998
Same author

[The reduction of the extension and severity of experimental myocardial infarct in pigs with growth hormone. The preservation of the microcirculation].

Archivos del Instituto de Cardiologia de Mexico·1993
Same author

Preservation of the myocardial collagen framework by human growth hormone in experimental infarctions and reduction in the incidence of ventricular aneurysms.

International journal of cardiology·1992
Same author

Bivalent effects of human growth hormone in experimental myocardial infarcts. Protective when administered alone and aggravating when combined with beta blockers.

Japanese heart journal·1990
Same journal

Protein extractabilities from the erythrocyte membranes in patients with chorea-acanthocytosis.

The Japanese journal of experimental medicine·1990
Same journal

Estrogen and progesterone receptor levels in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors in each week--check points about experimental studies using DMBA-induced tumors.

The Japanese journal of experimental medicine·1990
Same journal

Aggregated distribution of infective spots composed of Leptotrombidium pallidum, highly prevalent with Rickettsia tsutsugamushi, demonstrated by sentinel voles, Microtus montebelli, on the ground.

The Japanese journal of experimental medicine·1990
Same journal

Suppression of footpad reaction in mice by anthralin.

The Japanese journal of experimental medicine·1990
Same journal

Characterization and change of phospholipids in the aorta of Watanabe hereditable hyperlipidemic rabbit.

The Japanese journal of experimental medicine·1990
Same journal

A new technique of in vitro assay of antifilarials using different life-forms of Acanthocheilonema viteae.

The Japanese journal of experimental medicine·1990
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

A new model explains early ventricular aneurysm formation due to localized loss of heart muscle contractility and cell compression. Scar tissue can interrupt this process, correlating with aneurysm incidence.

Area of Science:

  • Cardiovascular Physiology
  • Biomechanical Modeling
  • Pathology

Background:

  • Ventricular aneurysms result from complex cardiac structural changes.
  • Early formation mechanisms, particularly involving cellular dynamics and forces, require further elucidation.

Purpose of the Study:

  • To develop a geometrical-dynamical model simulating the initial stages of ventricular aneurysm development.
  • To investigate the role of localized loss of contractility and resulting compressive forces.
  • To explore the influence of the extracellular matrix and scar formation on aneurysm progression.

Main Methods:

  • Design of a geometrical-dynamical model based on cellular contractility and packing.
  • Simulation of compressive stresses and their effects on cardiac tissue.

Related Experiment Videos

  • Correlation of model predictions with established pathological findings of ventricular aneurysms.
  • Analysis of the 'barrier effect' related to extracellular matrix composition and scar quality.

    • Main Results:

    • The model successfully reproduces early ventricular aneurysm formation driven by localized loss of contractility and abnormal cell packing.
    • Compressive forces between altered and normal cells are identified as a key factor in disease progression.
    • The model aligns with pathological observations such as wavy/broken fibers and apical aneurysm incidence.
    • A 'barrier effect' mediated by the extracellular matrix can interrupt aneurysm formation, with scar quality influencing incidence.

    Conclusions:

    • The geometrical-dynamical model provides a framework for understanding ventricular aneurysm pathogenesis.
    • Localized loss of contractility and subsequent mechanical stresses are critical early events.
    • Extracellular matrix properties, particularly scar formation, significantly modulate aneurysm development risk.