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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Consolidating drug data on a global scale using Linked Data.

Milos Jovanovik1, Dimitar Trajanov2

  • 1Faculty of Computer Science and Engineering, 'Ss. Cyril and Methodius' University in Skopje, Rugjer Boshkovikj 16, P.O. Box 393, Skopje, 1000, Macedonia. milos.jovanovik@finki.ukim.mk.

Journal of Biomedical Semantics
|January 23, 2017
PubMed
Summary

We created a global Linked Drug Data dataset by consolidating information from 23 countries. This comprehensive dataset enables new data-driven applications for drug product information worldwide.

Keywords:
Data consolidationDrug productsDrugsHealthcareLinked dataMethodologyOpen dataTools

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Area of Science:

  • Biomedical Informatics
  • Data Science
  • Pharmacovigilance

Background:

  • Drug product data is fragmented globally due to national regulatory domains.
  • Inconsistent data formats, languages, and structures hinder data integration.
  • Linked Data principles offer a solution for de-siloing and consolidating drug information.

Purpose of the Study:

  • To develop methodological guidelines and tools for generating global Linked Drug Data.
  • To create a comprehensive, consolidated dataset of drug product information.
  • To enable data-driven applications and new usage scenarios for drug data.

Main Methods:

  • Developed a methodology and tools for generating Linked Data in the drug domain.
  • Applied these tools to transform, consolidate, and publish drug data from 23 countries.
  • Ensured high-quality, 5-star Linked Drug Data publication.

Main Results:

  • Generated the LinkedDrugs dataset, containing over 248,000 drug products.
  • The dataset comprises over 99 million RDF triples and links to generic drugs.
  • Demonstrated the dataset's capability to support advanced drug domain usage scenarios.

Conclusions:

  • The methodology and tools effectively transform distributed drug data into a unified Linked Drug Data dataset.
  • A de-siloed, consolidated drug data space offers significant advantages for users and analysis.
  • The LinkedDrugs dataset showcases the power of the Web's infrastructure for accessing comprehensive drug information.