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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

9.5K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Related Experiment Video

Updated: Mar 8, 2026

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells
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Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells

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Studying hematopoiesis using single-cell technologies.

Fang Ye1, Wentao Huang1, Guoji Guo2

  • 1Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.

Journal of Hematology & Oncology
|January 23, 2017
PubMed
Summary
This summary is machine-generated.

Single-cell analysis is revolutionizing the study of hematopoietic stem cells (HSCs) and their differentiation. This technology provides unprecedented multi-omic resolution, challenging traditional models and advancing regenerative medicine in hematology.

Keywords:
Hematopoietic stem cellLineage hierarchyRegulatory networkSingle-cell analysis

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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Area of Science:

  • Hematology
  • Stem cell biology
  • Genomics
  • Proteomics
  • Epigenomics

Background:

  • Hematopoiesis, the process of blood cell formation, is a well-studied stem cell differentiation system.
  • Hematopoietic stem cell (HSC) transplantation is a leading regenerative therapy.
  • Classical models of hematopoietic hierarchy based on cell surface markers are increasingly challenged by cell heterogeneity.

Purpose of the Study:

  • To review recent advances in single-cell analysis technologies for studying hematopoiesis.
  • To discuss the applications of these technologies in basic and clinical hematology.
  • To highlight the impact of multi-omic single-cell analysis on understanding hematopoietic stem cells.

Main Methods:

  • Single-cell genomics
  • Single-cell transcriptomics
  • Single-cell proteomics
  • Single-cell epigenomics
  • Multi-omic single-cell analysis

Main Results:

  • New technologies enable multi-omic analysis at single-cell resolution.
  • Single-cell approaches reveal heterogeneity within classical hematopoietic cell types.
  • These advancements offer a deeper understanding of hematopoietic stem cell differentiation and function.

Conclusions:

  • Single-cell technologies are transforming the study of hematopoiesis.
  • These methods provide unprecedented insights into stem cell heterogeneity and lineage development.
  • The application of single-cell multi-omic analysis holds significant promise for basic research and clinical applications in hematology.