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Related Experiment Video

Updated: Mar 8, 2026

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection

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Published on: July 16, 2018

Minocycline-Induced Hyperpigmentation Mimicking Aortic Dissection.

Tinera Buckley¹, Justin Lee², Keith E Gipson²

¹Department of Pathology, Hartford Hospital, Hartford, Connecticut.

The Annals of Thoracic Surgery

|January 23, 2017

Summary

Minocycline can cause tissue hyperpigmentation, rarely affecting the cardiovascular system. This case highlights differentiating drug-induced discoloration from serious conditions during surgery.

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Area of Science:

Cardiovascular Pathology
Pharmacology
Surgical Management

Background:

Minocycline is an antibiotic known to cause tissue hyperpigmentation.
Cardiovascular involvement is an uncommon manifestation of minocycline-induced hyperpigmentation.

Observation:

A patient presented with significant cardiovascular discoloration after prolonged minocycline use (approximately 4 years).
Intraoperative assessment was crucial for distinguishing this drug-induced pigmentation from other pathological causes.

Findings:

The cardiovascular tissues exhibited marked hyperpigmentation attributed to minocycline exposure.
Accurate intraoperative differentiation enabled appropriate surgical decision-making.

Implications:

This case underscores the importance of considering iatrogenic causes for cardiovascular discoloration.
Awareness of minocycline's potential cardiovascular effects aids in surgical planning and patient management.