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[Infectious risk related to the formation of multi-species biofilms (Candida - bacteria) on peripheral vascular

A Seghir1, Z Boucherit-Otmani2, L Sari-Belkharroubi2

  • 1Laboratoire antibiotiques antifongiques : physicochimie synthèse et activité biologique, université de Tlemcen, Tlemcen, Algérie; Université de Saida, Saida, Algérie.

Journal De Mycologie Medicale
|January 23, 2017
PubMed

Insights

Candida yeasts and bacteria form drug-resistant mixed biofilms on medical implants. These persistent infections act as pathogen reservoirs with poorly understood interactions.

Area of Science:

  • Medical microbiology
  • Infectious diseases
  • Biomaterials science

Background:

  • Candida yeasts are a leading cause of systemic infections.
  • Co-infections with bacteria increase infection severity.
  • Medical implants are susceptible to microbial colonization.

Purpose of the Study:

  • To investigate the formation and implications of mixed biofilms on medical implants.
  • To understand the interactions between Candida yeasts and bacteria in biofilms.
  • To explore the role of mixed biofilms as persistent pathogen reservoirs.

Main Methods:

  • In vitro studies of yeast-bacterial co-adherence to implant materials.
  • Microscopy techniques to visualize mixed biofilm structure.
  • Antimicrobial susceptibility testing of mixed biofilms.

Main Results:

  • Mixed biofilms of Candida yeasts and bacteria readily form on implant surfaces.
  • These mixed biofilms exhibit increased resistance to antimicrobial agents.
  • Mixed biofilms serve as persistent reservoirs for recalcitrant infections.

Conclusions:

  • Mixed biofilms on medical implants pose a significant challenge in treating systemic infections.
  • Further research into yeast-bacterial interactions within biofilms is crucial.
  • Understanding these interactions may lead to novel therapeutic strategies.
Keywords:
BacteriaBactériesBiofilmsCandidaCathéters vasculaires périphériquesMulti-espècesMulti-speciesPeripheral vascular catheters

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