Simulation and evaluation of rupturable coated capsules by finite element method

Area of Science:

• Materials Science
• Pharmaceutical Engineering
• Computational Mechanics

Background:

• Coated capsules are crucial for controlled drug delivery.
• Understanding capsule burst behavior is essential for formulation design.
• Predictive modeling can optimize capsule performance.

Purpose of the Study:

• To simulate and evaluate the burst behavior of rupturable coated capsules using the finite element method (FEM).
• To validate FEM models against experimental data.
• To predict coating burst behavior and optimize formulations.

Main Methods:

• Coated capsules prepared via dip-coating; dimensions measured by stereomicroscope.
• Mechanical properties determined by tensile testing for FEM material properties.
• Swelling pressure and water uptake measured to simulate internal pressure.

Main Results:

• FEM simulations showed good agreement with experimental burst test and in vitro dissolution results.
• Swelling pressure, material properties, and coating dimensions significantly influenced maximum stress.
• Burst pressure and critical L-HPC content were calculated for formulation optimization.

Conclusions:

• FEM simulation is a feasible and effective method for evaluating coated capsule burst behavior.
• The study provides a predictive tool for optimizing capsule formulations.
• This approach can guide the design of rupturable coated capsules for specific applications.