Related Experiment Video
Updated: Mar 8, 2026
09:50
Preparation and Reactivity of Gasless Nanostructured Energetic Materials
Published on: April 2, 2015
10.7K
Composite particles based on particle engineering for direct compaction
1College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
International Journal of Pharmaceutics
|January 23, 2017
Summary
Particle engineering via co-processing enhances the functionality of active pharmaceutical ingredients (APIs) and excipients. This improves direct compaction (DC) for tablet manufacturing, overcoming limitations of current APIs.
Area of Science:
- Pharmaceutical Technology
- Materials Science
- Chemical Engineering
Background:
- Direct compaction (DC) is a preferred tablet manufacturing method.
- Most active pharmaceutical ingredients (APIs) lack the necessary properties for successful DC.
- Particle engineering offers a solution to improve API and excipient functionality.
Purpose of the Study:
- To review recent advancements in particle engineering for direct compaction.
- To summarize improvements in functional properties of co-processed particles.
- To discuss the mechanisms behind enhanced particle functionality.
Main Methods:
- Review of recent developments and research in particle engineering.
- Analysis of co-processing techniques for composite API/excipient particles.
- Discussion of structure-property relationships at crystal and particle levels.
Main Results:
- Co-processing significantly enhances the functional properties of API and excipient particles.
- Improved particle properties enable successful direct compaction tableting.
- Structure characteristics (crystal and particle levels) are key determinants of improved functionality.
Conclusions:
- Particle engineering via co-processing is a viable strategy to overcome limitations in direct compaction.
- Understanding structure-property relationships is crucial for designing effective co-processed particles.
- This approach broadens the applicability of direct compaction in pharmaceutical manufacturing.
Related Concept Videos
01:22Compacting Factor test
662
The compacting factor test is a method used to assess the workability of concrete. It is especially suitable for concrete mixes containing aggregates up to one and a half inches in size. This test involves specialized equipment consisting of two truncated cone-shaped hoppers and a cylinder, all with polished interior surfaces to minimize friction.
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...
662
01:29Preplaced Aggregate Concrete
426
Preplaced aggregate concrete is ideal for construction environments that are not easily accessible. The process begins by properly wetting the gap-graded coarse aggregates to remove the dirt, then placing it in the form and compacting it. Voids are filled with a mortar mix pumped under pressure through slotted pipes. This mortar typically consists of Portland cement, pozzolan, fine aggregates, water, and a fluidizing aid. The pozzolan helps reduce bleeding and segregation while improving the...
426
01:16Precipitate Formation and Particle Size Control
7.0K
In precipitation gravimetry, the precipitating agent should react specifically or selectively with the analyte. While a specific reagent reacts with the analyte alone, a selective reagent can react with a limited number of chemical species.
The obtained precipitate should be either a pure substance of known composition or easily converted to one by a simple process, such as ignition or drying. In addition, the precipitate should be insoluble and easily filterable. In general, filterability...
The obtained precipitate should be either a pure substance of known composition or easily converted to one by a simple process, such as ignition or drying. In addition, the precipitate should be insoluble and easily filterable. In general, filterability...
7.0K
01:14Design Example: Managing Concrete Workability
322
This example deals with managing the workability of concrete for a raft foundation project under hot weather conditions. Workability is crucial for ensuring the concrete is easy to place, compact, and finish. In this scenario, a slump test — a common method to measure the workability of fresh concrete — initially indicated low workability. This was attributed to the rapid water loss from the concrete mix, exacerbated by the high temperatures causing the course aggregates to heat up.
322
01:30Superplasticizers
401
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
401
01:13Pumped Concrete
443
Concrete in large quantities can be pumped across long distances for placing in inaccessible sites. This system comprises a hopper that receives concrete from a mixer, a pump to propel the concrete, and pipelines that facilitate its delivery.
For direct-acting pumps, the concrete enters the pump via the inlet valve under the action of gravity and suction created by the movement of the piston. This concrete is then forced into the pipeline and out through the outlet valve by the forward movement...
For direct-acting pumps, the concrete enters the pump via the inlet valve under the action of gravity and suction created by the movement of the piston. This concrete is then forced into the pipeline and out through the outlet valve by the forward movement...
443