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Bioactive nutrients - Time for tolerable upper intake levels to address safety
Allison A Yates1, John W Erdman2, Andrew Shao3
1Food and Nutrition Board, Institute of Medicine, National Research Council, Johnson City, TN 37615, United States.
Regulatory Toxicology and Pharmacology : RTP
|January 23, 2017
Summary
Consumers, researchers, and regulators are exploring bioactive compounds from natural sources for health benefits. Establishing safe intake levels requires toxicologist involvement in safety assessments and guidance development.
Area of Science:
- Nutritional Science
- Toxicology
- Pharmacology
Background:
- Growing consumer and regulatory interest in bioactive compounds from natural sources (plants, animals) for health.
- Emerging research suggests health benefits from compounds in fruits, vegetables, tea, cocoa, fish, and probiotics.
- Need for evidence-based dietary guidance and recommended intakes for bioactive substances.
Purpose of the Study:
- To explore the establishment of recommended intakes for bioactive substances.
- To highlight the critical role of safety and toxicity assessments in dietary guidance.
- To emphasize the necessity of toxicologist involvement in developing safety frameworks.
Main Methods:
- Review of emerging research on bioactive compounds and their health effects.
- Analysis of the process for establishing dietary guidance.
- Identification of toxicological requirements for safety assessments.
Main Results:
- Significant health benefits are suggested for various bioactive compounds from natural origins.
- Safety assessment and toxicity evaluation are crucial for setting dietary recommendations.
- Toxicologists are essential for developing safety frameworks and upper intake limits.
Conclusions:
- Dietary guidance for bioactive compounds requires robust safety evaluations.
- Collaboration between researchers and toxicologists is vital for consumer health and safety.
- Further research and regulatory frameworks are needed to harness the health potential of natural bioactive compounds.
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