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Long-term usability and bio-integration of polyimide-based intra-neural stimulating electrodes.

S Wurth¹, M Capogrosso², S Raspopovic²

¹Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; International Paraplegic Foundation Chair in Spinal Cord Repair, Center for Neuroprosthetics and Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

|January 23, 2017

Summary

Polyimide intra-neural electrodes show stable function and biocompatibility for over six months in rat sciatic nerves. This research supports long-term clinical applications for restoring sensation and motor function.

Keywords:

Biocompatibility Control Intra-neural electrode Selectivity Stability

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Area of Science:

Biomedical Engineering
Neuroscience
Materials Science

Background:

Intra-neural implants offer potential for restoring sensation and motor function.
Long-term usability and bio-integration of these implants require further characterization for clinical translation.

Purpose of the Study:

To longitudinally assess the selectivity, stability, functionality, and biocompatibility of polyimide-based intra-neural implants.
To investigate the foreign body response and its impact on implant performance over six months.

Main Methods:

Implantation of polyimide intra-neural electrodes into the sciatic nerve of 23 rats for up to six months.
Longitudinal assessment of electrode stimulation threshold, impedance, and selectivity.
Histological analysis of implant encapsulation, nerve tissue, and foreign body response.
Evaluation of motor function before and after implant removal.

Main Results:

Electrode stimulation threshold and impedance moderately increased in the first four weeks, then stabilized.
A fibrotic capsule formed around implants, correlating with electrical property changes.
Stable electrode selectivity allowed precise control of ankle muscles.
Foreign body response evolved, with initial macrophage infiltration followed by giant cell formation, without affecting nerve fiber density.
No significant alteration in skilled leg movements was observed after implant removal.

Conclusions:

Polyimide-based intra-neural implants demonstrate functional stability and biocompatibility for over six months.
The study characterizes the interplay between foreign body response and electrical properties of active electrodes.
Findings support the realistic pathway for long-term clinical applications of intra-neural electrodes.