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Explosive Blast Loading on Human 3D Aggregate Minibrains
Nicole E Zander1, Thuvan Piehler2, Helena Hogberg3
1Department of the Army, US Army Research Laboratory, Weapons and Materials Research Directorate, RDRL-WMM-G, Building 4600, Aberdeen Proving Ground, MD, 21005, USA. nicole.e.zander.civ@mail.mil.
Cellular and Molecular Neurobiology
|January 23, 2017
Abstract:
The effects of primary explosive blast on brain tissue still remain mostly unknown. There are few in vitro models that use real explosives to probe the mechanisms of injury at the cellular level. In this work, 3D aggregates of human brain cells or brain microphysiological system were exposed to military explosives at two different pressures (50 and 100 psi). Results indicate that membrane damage and oxidative stress increased with blast pressure, but cell death remained minimal.