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Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry
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Mass Spectrometry Imaging in Oncology Drug Discovery

R J A Goodwin1, J Bunch2, D F McGinnity3

  • 1Mass Spectrometry Imaging Group, Pathology Sciences, Drug Safety & Metabolism, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom.

Advances in Cancer Research
|January 24, 2017
PubMed

Insights

Mass spectrometry imaging (MSI) is revolutionizing oncology drug discovery by assessing compound efficacy and safety within the tumor microenvironment. This technology aids in understanding drug biodistribution and pharmacokinetics for improved therapeutic development.

Area of Science:

  • Oncology
  • Pharmacology
  • Analytical Chemistry

Background:

  • Mass spectrometry imaging (MSI) has become integral to modern drug discovery and development.
  • Its application in oncology is particularly impactful for evaluating drug performance within the complex tumor microenvironment.

Purpose of the Study:

  • To discuss the diverse roles of MSI in drug discovery and development.
  • To highlight specific applications of MSI in oncology research, including tumor metabolism.
  • To address the challenges and advancements in applying MSI in industrial research.

Main Methods:

  • Review of MSI applications in drug discovery.
  • Discussion of MSI for biodistribution and pharmacokinetic-pharmacodynamic (PK-PD) analyses.
  • Exploration of MSI for tumor microenvironment and metabolism studies.

Main Results:

  • MSI enables assessment of compound efficacy and safety in oncology.
  • MSI facilitates understanding of compound and metabolite biodistribution.
  • MSI aids in defining PK-PD relationships applicable across drug discovery projects.

Conclusions:

  • MSI is a powerful tool for oncology drug discovery, offering insights into efficacy, safety, and tumor metabolism.
  • The technology supports biodistribution and PK-PD analyses crucial for all drug development.
  • Advancements in metrology are enhancing the application of MSI in industry research.
Keywords:
PK/PDdrug deliverymicroenvironment

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