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MALDI-TOF Mass Spectrometry

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...

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Related Experiment Video

Updated: Mar 8, 2026

Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples

Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples

Published on: June 29, 2022

MALDI IMS and Cancer Tissue Microarrays.

R Casadonte¹, R Longuespée¹, J Kriegsmann²

¹Proteopath GmbH, Trier, Germany.

Advances in Cancer Research

|January 24, 2017

Summary

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) offers molecular insights alongside spatial distribution data. This technology is advancing for routine cancer diagnostics using formalin-fixed paraffin-embedded tissue microarrays.

Keywords:

Cancer FFPE IMS MALDI TMA Tissue microarrays

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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

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Last Updated: Mar 8, 2026

Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples

Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples

Published on: June 29, 2022

Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization IR-MALDESI

Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization IR-MALDESI

Published on: March 24, 2016

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Area of Science:

Biomedical Mass Spectrometry
Molecular Pathology
Cancer Research Technology

Background:

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) integrates molecular and spatial information.
Formalin-fixed paraffin-embedded (FFPE) tissue microarrays (TMAs) are valuable for large-scale discovery analyses.

Purpose of the Study:

To provide a comprehensive overview of MALDI IMS applications on FFPE cancer TMAs.
To detail technical aspects and considerations for implementing MALDI IMS in cancer research.

Main Methods:

Application of MALDI IMS on FFPE tissue microarrays.
Analysis of molecular profiles and their spatial distribution in cancer tissues.

Main Results:

Promising data from FFPE TMA cancer samples indicate high potential for MALDI IMS.
MALDI IMS technology is rapidly advancing for clinical applications.

Conclusions:

MALDI IMS on FFPE TMAs is a powerful tool for cancer discovery analyses.
The technology is poised for integration into routine cancer diagnostics in the near future.