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[Immune response and digestive cancers: Prognostic and therapeutic implications]
Frédéric Bibeau1, Céline Bazille1, Magali Svrcek2
1Service d'anatomie et cytologie pathologiques, Unicaen, CHU de Caen, université de Caen, 14003 Caen, France.
Annales De Pathologie
|January 24, 2017
Summary
The immune response significantly impacts digestive cancers, particularly colorectal cancer (CRC). Adaptive lymphocytic infiltrate indicates a favorable prognosis and predicts response to immunotherapy, highlighting its role in precision medicine.
Area of Science:
- Oncology
- Immunology
- Gastroenterology
Background:
- The immune response plays a critical role in the progression and treatment of digestive cancers.
- Colorectal cancer (CRC) exhibits varying immune profiles that influence patient outcomes.
- Understanding these immune interactions is crucial for advancing precision medicine in oncology.
Purpose of the Study:
- To highlight the prognostic and predictive significance of the immune response in digestive cancers, with a focus on colorectal cancer.
- To discuss the role of adaptive lymphocytic infiltrate as a biomarker in CRC.
- To explore the potential of immune response biomarkers in guiding adjuvant therapy and predicting response to immunotherapy.
Main Methods:
- Review and analysis of existing literature on immune response in digestive cancers.
- Examination of the prognostic impact of lymphocytic infiltrate in colorectal cancer.
- Evaluation of immune response as a predictive biomarker in microsatellite instable metastatic CRC.
- Discussion on methodologies for assessing prognostic and predictive biomarkers.
Main Results:
- Adaptive lymphocytic infiltrate is associated with a favorable prognosis in colorectal cancer.
- Microsatellite instable metastatic CRC with lymphocytic infiltrate shows high response rates to immune therapies.
- Immune response biomarkers are valuable for patient selection in adjuvant therapy and immunotherapy.
Conclusions:
- The immune response, particularly lymphocytic infiltrate, is a key factor in the prognosis and treatment of colorectal cancer.
- Further validation of immune response biomarkers in prospective trials is necessary for integrating them into clinical decision-making.
- Optimization of prognostic and predictive biomarkers is essential for personalized treatment strategies in digestive cancers.
Keywords:
Cancers colorectauxCancers digestifsColorectal cancerDigestive cancerImmune responsePredictionPrognosticPronosticPrédictionRéponse immuneMore Related Videos
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