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Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

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New bunya-like viruses: Highlighting their relations.

Alexandro Guterres¹, Renata Carvalho de Oliveira², Jorlan Fernandes²

¹Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil; Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases

|January 24, 2017

Summary

Phylogenetic analysis reveals that arenaviruses and bunyaviruses, previously classified separately, share a common evolutionary origin. This discovery redefines our understanding of viral family origins and genome evolution.

Keywords:

Arenaviruses Bunyavirus supergroup Bunyaviruses Evolutionary history Orthobunyaviruses Phleboviruses Tospoviruses

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Area of Science:

Virology
Evolutionary Biology
Bioinformatics

Background:

The classification of arenaviruses and bunyaviruses has been challenged by the discovery of divergent viruses in insect collections.
Despite differences in morphology, structure, and genetics, recent findings suggest a shared evolutionary origin for these viral families.

Purpose of the Study:

To determine the phylogenetic relationships among arenaviruses, bunyaviruses, and related viral groups.
To investigate the evolutionary interconnectedness and potential shared ancestry of these viruses.

Main Methods:

Inferred phylogenetic trees using Maximum Likelihood, Bayesian inference, and BEAST (Bayesian Evolutionary Analysis Sampling Trees) with molecular clock rooting.
Analyzed viral morphology, structure, and genetic data.

Main Results:

Identified at least three well-supported monophyletic supergroups, indicating a noteworthy evolutionary relationship among these viral supergroups with different genome organizations.
Demonstrated that these viruses are evolutionarily and genetically interconnected, despite variations in their genomic structures.

Conclusions:

The findings suggest a shared evolutionary origin for arenaviruses and bunyaviruses, necessitating a revised classification scheme.
This research provides new perspectives on viral family origins, diversity, and genome evolution, highlighting the need for further investigation of related viruses.