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Inhibition of Propionibacterium acnes lipase activity by the antifungal agent ketoconazole

Mizuki Unno1, Otomi Cho1, Takashi Sugita1

  • 1Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

Microbiology and Immunology
|January 24, 2017
PubMed

Insights

Ketoconazole, an antifungal drug, shows promise for treating acne vulgaris. It inhibits the bacteria Propionibacterium acnes and its lipase, offering an alternative to antibiotics due to rising resistance.

Area of Science:

  • Dermatology
  • Microbiology
  • Pharmacology

Background:

  • Acne vulgaris is a common skin condition caused by Propionibacterium acnes.
  • Propionibacterium acnes secretes lipase, which metabolizes sebum, leading to skin inflammation.
  • Increasing antibiotic resistance in P. acnes necessitates alternative acne treatments.

Purpose of the Study:

  • To investigate the potential of ketoconazole as an alternative treatment for acne vulgaris.
  • To evaluate ketoconazole's effect on P. acnes lipase activity and bacterial growth.

Main Methods:

  • Assessing the inhibitory effects of ketoconazole on P. acnes lipase.
  • Evaluating the impact of ketoconazole on P. acnes growth in vitro.

Main Results:

  • Ketoconazole effectively inhibits P. acnes lipase activity.
  • Ketoconazole was previously shown to inhibit the growth of P. acnes.

Conclusions:

  • Ketoconazole demonstrates dual action against P. acnes by inhibiting lipase and growth.
  • Ketoconazole presents a potential therapeutic alternative for acne vulgaris, addressing antibiotic resistance concerns.
Keywords:
Propionibacterium acnesketoconazolelipase

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