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Updated: Mar 8, 2026
Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
Published on: April 19, 2017
Association between C-reactive protein levels in the first 1-3 days post-transplant and allogeneic immune reactions
Yao Chen1, Xiao-Jun Huang1, Kai-Yan Liu1
1Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, 11 Xizhimen South Street, Beijing 100044, PR China.
Aim:
The purpose of this study was to determine whether C-reactive protein (CRP) in the first 1-3 days post-transplant could predict allogeneic immune reactions, including engraftment syndrome or acute graft-versus-host disease (GVHD), in pediatric haploidentical stem cell transplantation.
Patients & Methods:
The study population comprised 175 consecutive pediatric patients. Receiver operating characteristic analysis was performed to identify the cut-off CRP value.
Results:
The high-CRP group (≥20.1 mg/l) was associated with an increased occurrence of engraftment syndrome (hazard ratio [HR] = 2.046; p = 0.008), II-IV acute GVHD (HR = 2.203; p = 0.001) and severe GVHD (HR = 6.371; p = 0.004).
Conclusion:
Our data suggest that higher CRP during the first 1-3 days post-transplant could be a predictor of allogeneic immune reactions.
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