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Published on: January 31, 2018
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Crosstalk between the nucleolus and the DNA damage response
1Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA. susan.baserga@yale.edu.
Molecular Biosystems
|January 24, 2017
Summary
The DNA damage response and nucleolar function are interconnected. DNA repair proteins aid ribosome biogenesis, while ribosome proteins assist DNA repair, revealing a crucial crosstalk.
Area of Science:
- Cellular Biology
- Molecular Biology
- Genetics
Background:
- Nucleolar function and DNA damage response were traditionally viewed as separate cellular processes.
- Emerging research highlights proteins with multiple roles, suggesting crosstalk between cellular mechanisms.
- The nucleolus is a key site for ribosome biogenesis and increasingly recognized for its role in DNA repair.
Purpose of the Study:
- To explore the crosstalk between the DNA damage response and the nucleolus.
- To review the literature on the interplay between DNA repair proteins and ribosome biogenesis.
- To identify potential new therapeutic targets by understanding this overlap.
Main Methods:
- Comprehensive literature review focusing on DNA repair and nucleolar function.
- Analysis of recent advances in nucleolar proteomics.
- Identification of proteins with dual roles in DNA repair and ribosome biogenesis.
Main Results:
- Conventional DNA repair proteins have been found to play roles in ribosome biogenesis.
- Proteins involved in ribosome biogenesis also contribute to DNA repair mechanisms.
- New DNA repair proteins with nucleolar-specific functions are likely to be identified.
Conclusions:
- There is significant crosstalk between the DNA damage response and the nucleolus.
- Understanding this overlap is crucial for advancing both fields.
- Elucidating these connections may lead to novel therapeutic strategies for various pathologies.
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