Niche Extracellular Matrix Components and Their Influence on HSC
Mélanie J Domingues1,2, Huimin Cao1,2, Shen Y Heazlewood1,2
1Manufacturing, Commonwealth Scientific and Industrial Research Organization, Bag 10, Clayton South, VIC 3169, Australia.
Journal of Cellular Biochemistry
|January 24, 2017
Summary
The bone marrow niche, once thought static, is a dynamic environment regulating hematopoietic stem cells (HSC). Extracellular matrix and non-protein metabolites like lipids and metal ions are key to HSC fate.
Area of Science:
- Hematology
- Stem Cell Biology
- Biochemistry
Background:
- Hematopoietic stem cells (HSC) reside in a specialized bone marrow microenvironment.
- In vivo imaging has revealed the niche as a dynamic regulator of HSC homeostasis, involving cellular, molecular, and extracellular components.
- Non-protein metabolites are increasingly recognized as crucial niche components.
Purpose of the Study:
- To review the current understanding of how extracellular matrix components regulate HSC fate during development and adulthood.
- To highlight the role of non-protein metabolites, including lipids and metal ions, in HSC behavior.
Main Methods:
- This is a review article, synthesizing existing research.
- Focuses on analyzing data from in vivo imaging and molecular studies.
- Integrates findings on extracellular matrix composition and metabolite functions.
Main Results:
- The bone marrow niche is a complex, dynamic system, not a static support.
- Extracellular matrix molecules and non-protein metabolites actively regulate HSC fate.
- Lipids and metal ions are significant regulators of HSC behavior within the niche.
Conclusions:
- The bone marrow niche's complexity extends beyond proteins to include metabolites.
- Understanding these components is vital for comprehending HSC regulation.
- Further research into niche metabolites could reveal new therapeutic targets for HSC disorders.
Keywords:
EXTRACELLULAR MATRIX MOLECULESHEMATOPOIETIC STEM CELLSINTEGRINSLIPIDSMEGAKARYOCYTESMETAL IONSMICROENVIRONMENTNICHEMore Related Videos
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