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Snail/Slug-YAP/TAZ complexes cooperatively regulate mesenchymal stem cell function and bone formation

Yi Tang1,2, Stephen J Weiss1,2

  • 1a Division of Molecular Medicine and Genetics, Department of Internal Medicine , University of Michigan , Ann Arbor , MI , USA.

Cell Cycle (Georgetown, Tex.)
|January 24, 2017
PubMed

Insights

Snail/Slug and YAP/TAZ transcription factors cooperate to control stem cell self-renewal and differentiation. This interaction is crucial for bone development and may regulate stem cells in tissue regeneration, fibrosis, and cancer.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Snail and Slug are transcription factors regulating epithelial-mesenchymal transition (EMT).
  • YAP and TAZ are Hippo pathway co-transcriptors controlling stem cell self-renewal and lineage commitment.
  • Previous research had not described direct links between Snail/Slug and Hippo pathways.

Purpose of the Study:

  • To investigate the interaction between Snail/Slug and YAP/TAZ.
  • To understand the role of this interaction in mesenchymal stem cell (MSC) function.
  • To explore the implications for development, regeneration, and disease.

Main Methods:

  • Investigated cooperative interactions between Snail/Slug and YAP/TAZ.
  • Studied the control of MSC self-renewal and differentiation.
  • Analyzed the formation of binary complexes between these factors.

Main Results:

  • An unexpected cooperative interaction between Snail/Slug and YAP/TAZ was identified.
  • This axis controls self-renewal and differentiation of bone marrow-derived MSCs.
  • Snail and Slug form binary complexes with YAP or TAZ, regulating their activity during mouse development.

Conclusions:

  • The Snail/Slug-YAP/TAZ axis is critical for regulating stem cell properties in bone development.
  • This pathway is poised to influence stem cell function in vascular-associated MSCs involved in regeneration, fibrosis, and cancer.
  • Understanding this axis offers insights into stem cell regulation in health and disease.
Keywords:
HippoRUNX2SlugSnailTAZTEADYAPmesenchymal stem cellsskeletal stem cells

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