Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Duplication and Divergence02:37

Gene Duplication and Divergence

8.1K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
8.1K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

19.2K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
19.2K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

8.3K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
8.3K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

3.8K
3.8K
Gene Conversion02:08

Gene Conversion

10.8K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Continuous approximations for the fixation probability of the Moran processes on star graphs.

Journal of mathematical biology·2025
Same author

Closing the Complexity Gap of the Double Distance Problem.

IEEE transactions on computational biology and bioinformatics·2025
Same author

Family-Free Genome Comparison.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Another view of sequential sampling in the birth process with immigration.

Journal of mathematical biology·2024
Same author

Investigating the complexity of the double distance problems.

Algorithms for molecular biology : AMB·2024
Same author

Efficient gene orthology inference via large-scale rearrangements.

Algorithms for molecular biology : AMB·2023

Related Experiment Video

Updated: Mar 8, 2026

Digital-Droplet PCR to Detect Indels Mutations in Genetically Modified Anopheline Mosquito Populations
05:51

Digital-Droplet PCR to Detect Indels Mutations in Genetically Modified Anopheline Mosquito Populations

Published on: June 28, 2021

4.0K

Genomic Distance with High Indel Costs.

Poly H da Silva, Raphael Machado, Simone Dantas

    IEEE/ACM Transactions on Computational Biology and Bioinformatics
    |January 24, 2017
    PubMed
    Summary

    We present an efficient linear-time formula for calculating the DCJ-indel distance with distinct operation costs. An algorithm is also proposed to correct disruptions in the triangular inequality for DCJ-indel metrics.

    Area of Science:

    • Computational Biology
    • Bioinformatics
    • Genomics

    Background:

    • The DCJ-indel distance is a metric for genome rearrangements.
    • Understanding its computational complexity is crucial for phylogenetic analysis.
    • Previous methods may not efficiently handle distinct costs for different operations.

    Purpose of the Study:

    • To determine the computational complexity of the DCJ-indel distance.
    • To develop an efficient method for calculating this distance with variable operation costs.
    • To address the issue of triangular inequality disruption in DCJ-indel metrics.

    Main Methods:

    • Derivation of an exact formula for DCJ-indel distance.
    • Analysis of computational complexity, aiming for linear time.

    More Related Videos

    Infinium Assay for Large-scale SNP Genotyping Applications
    13:33

    Infinium Assay for Large-scale SNP Genotyping Applications

    Published on: November 19, 2013

    40.0K
    Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9
    09:40

    Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9

    Published on: January 3, 2015

    96.7K

    Related Experiment Videos

    Last Updated: Mar 8, 2026

    Digital-Droplet PCR to Detect Indels Mutations in Genetically Modified Anopheline Mosquito Populations
    05:51

    Digital-Droplet PCR to Detect Indels Mutations in Genetically Modified Anopheline Mosquito Populations

    Published on: June 28, 2021

    4.0K
    Infinium Assay for Large-scale SNP Genotyping Applications
    13:33

    Infinium Assay for Large-scale SNP Genotyping Applications

    Published on: November 19, 2013

    40.0K
    Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9
    09:40

    Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9

    Published on: January 3, 2015

    96.7K
  • Development of an efficient algorithmic correction for triangular inequality.

    • Main Results:

    • An exact formula for DCJ-indel distance computation in linear time was established.
    • The formula accommodates arbitrary constant costs for DCJ and indel operations.
    • An efficient algorithm was proposed to correct triangular inequality violations.

    Conclusions:

    • The DCJ-indel distance can be computed efficiently, even with distinct operation costs.
    • The proposed correction method enhances the reliability of DCJ-indel metrics.
    • This work provides a computationally feasible approach for evolutionary distance calculations.