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Granular cell lesions in head and neck: a clinicopathological study
D M Fliss1, M Puterman, H Zirkin
1E.N.T. Department, Soroka University Hospital, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Journal of Surgical Oncology
|November 1, 1989
Summary
This study compares adult and congenital granular cell lesions in the head and neck. Adult tumors show S100 protein, suggesting neural origin, unlike congenital forms.
Area of Science:
- Oral pathology
- Head and neck oncology
- Developmental biology
Background:
- Granular cell lesions present in both adult and congenital forms.
- Head and neck region is a common site for these lesions.
Purpose of the Study:
- To analyze and compare adult and congenital granular cell lesions in the head and neck.
- To investigate the histogenesis of these distinct lesion types.
Main Methods:
- Retrospective analysis of 25 head and neck granular cell lesion cases.
- Immunohistochemical staining for S100 protein and embryonic antigen.
Main Results:
- Adult granular cell tumors (18 cases) predominantly affected women, with common sites including tongue, skin, and subcutaneous tissues.
- Congenital granular cell epulides (7 cases) occurred in female infants on the maxillary or mandibular mucosa.
- S100 protein was positive in adult tumors but negative in congenital epulides.
- Embryonic antigen was present in most congenital and adult cases.
Conclusions:
- Adult and congenital granular cell lesions share morphological similarities but differ in histogenesis.
- S100 protein positivity supports a neural (Schwann cell) origin for adult granular cell tumors.
- The origin of congenital granular cell epulides remains distinct from the adult form.