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Updated: Mar 8, 2026

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
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Published on: May 18, 2017

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A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging

Alessio Lanna1,2, Daniel C O Gomes1,3, Bojana Muller-Durovic1

  • 1Division of Infection and Immunity, University College London, London, UK.

Nature Immunology
|January 24, 2017
PubMed
Summary

Sestrins form a complex that inhibits multiple mitogen-activated protein kinases (MAPKs) in T cells. Disrupting this complex rejuvenates immune function in aging, enhancing vaccine responses.

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