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Updated: Mar 8, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Functional Haplotypes in Interleukin 4 Gene Associated with Periodontitis

Giovana Anovazzi1,2, Marcell Costa de Medeiros1, Suzane Cristina Pigossi1,2

  • 1Department of Oral Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP- Univ Estadual Paulista, Araraquara, São Paulo, Brazil.

Plos One
|January 24, 2017
PubMed
Summary

Genetic variations in Interleukin 4 (IL-4) influence immune cell responses to chronic periodontitis (CP)-associated bacteria. The protective P-haplotype shows attenuated responses, while the susceptible S-haplotype exhibits heightened pro-inflammatory reactions.

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