Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 8, 2026

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

4.2K

Understanding Resonant Light-Triggered DNA Release from Plasmonic Nanoparticles.

Amanda M Goodman, Nathaniel J Hogan, Samuel Gottheim

  • 1Department of Surgery, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.

ACS Nano
|January 25, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inexpensive Hydrogen Storage: Propylene to Propane using Plasmonic Photocatalysis.

Nano letters·2026
Same author

Optimization of Agrobacterium-mediated transformation of commercial heirloom tomato cultivars to develop novel traits via CRISPR/Cas9 genome editing.

Planta·2026
Same author

Optical and electrical probing of plasmonic metal-molecule interactions.

Science advances·2025
Same author

Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: A novel path to cancer prevention.

International journal of cancer·2025
Same author

A Woman with Leg Numbness and Weakness.

The Journal of emergency medicine·2025
Same author

Medium-Chain Fatty Acid exposure in non-transformed mammary glands leads to pro-tumorigenic alterations associated with aging.

bioRxiv : the preprint server for biology·2025

Near-infrared light triggers release from gold nanoparticles for cancer therapy. Different lasers cause distinct DNA release mechanisms, impacting future gene and drug delivery systems.

Area of Science:

  • Biotechnology
  • Materials Science
  • Oncology

Background:

  • Nanoparticle platforms are increasingly used for cancer gene therapy and drug delivery.
  • Remote triggering of therapeutic cargo release using near-infrared (NIR) light enhances selectivity.
  • Understanding the mechanisms of NIR-triggered release from nanoparticle complexes is crucial.

Purpose of the Study:

  • To investigate the mechanisms of DNA release from plasmonic nanoparticle complexes.
  • To compare DNA release triggered by continuous wave (CW) and femtosecond pulsed lasers.
  • To elucidate the implications of different laser excitation types on release kinetics and mechanisms.

Main Methods:

  • Utilized gold nanoparticle complexes loaded with DNA.
  • Employed continuous wave (CW) and femtosecond pulsed lasers for excitation.
Keywords:
DNAlasernanoshellsoligonucleotidephotothermal heating

More Related Videos

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

8.0K
Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation
09:29

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation

Published on: September 27, 2011

12.7K

Related Experiment Videos

Last Updated: Mar 8, 2026

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

4.2K
Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

8.0K
Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation
09:29

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation

Published on: September 27, 2011

12.7K
  • Analyzed DNA release characteristics under different laser conditions.

    • Main Results:

    • Continuous wave (CW) laser illumination induced photothermal release of single-stranded DNA.
    • Femtosecond pulsed laser excitation resulted in double-stranded DNA release via Au-S bond cleavage with minimal heating.
    • The type of laser excitation profoundly altered the DNA release mechanism from the same nanoparticle complex.

    Conclusions:

    • The mechanism of DNA release from nanoparticle complexes is highly dependent on the laser excitation source.
    • Continuous wave (CW) lasers primarily utilize photothermal effects, while pulsed lasers can induce bond cleavage.
    • These findings have significant implications for designing targeted and efficient NIR-triggered gene and drug delivery systems for cancer therapy.