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Updated: Mar 8, 2026
Opsonophagocytic Killing Assay to Assess Immunological Responses Against Bacterial Pathogens
Published on: April 5, 2019
Development of a high-throughput opsonophagocytic assay for the determination of functional antibody activity against
Natalie Lorenz1, Jacelyn M S Loh1, Nicole J Moreland1
1Department of Molecular Medicine & Pathology, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand; Maurice Wilkins Centre, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
Abstract:
The lack of standardised protocols for the assessment of functional antibodies has hindered Streptococcus pyogenes research and the development of vaccines. A robust, high throughput opsonophagocytic bactericidal assay to determine protective antibodies in human and rabbit serum has been developed that utilises bioluminescence as a rapid read out.
